Article

Functional analyses of TET2 in vivo and in vitro reveal endothelial-specific roles in interferon responses that are dysregulated in hyperglycaemia

2024-09-18

Abstract excerpt

<title>Abstract</title> <p>Background Endothelial dysfunction represents a critical early event in the development of vascular disease but its aetiology remains unknown. However, risk factors for cardiovascular disease, including hyperglycaemia, correlate with altered DNA methylation patterns both <italic>in vivo</italic> and <italic>in vitro</italic>. Ten-Eleven-Translocation 2 (TET2) catalyses successive oxida...

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Literature Corpus work: 45dd09c8-af05-59a3-b0a1-3fca86c12ba3
DOI: 10.21203/rs.3.rs-4882148/v1

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