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Follicular helper T cell signature in type 1 diabetes

7 Dec 2014

Abstract excerpt

The strong genetic association between particular HLA alleles and type 1 diabetes (T1D) indicates a key role for CD4+ T cells in disease; however, the differentiation state of the responsible T cells is unclear. T cell differentiation originally was considered a dichotomy between Th1 and Th2 cells, with Th1 cells deemed culpable for autoimmune islet destruction. Now, multiple additional T cell differentiation...

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PMID: 25485678
DOI: 10.1172/jci76238

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