Article

Genome instability underlies an augmented DNA damage response in familial and sporadic ALS human iPSC-derived motor neurons

2022-09-21

Abstract excerpt

<title>Abstract</title> Amyotrophic Lateral Sclerosis (ALS) is characterised by progressive motor neuron degeneration, but there is marked genetic and clinical heterogeneity1. It has been challenging to identify common ALS mechanisms among this diversity; however, a systematic framework examining motor neurons across the ALS spectrum may reveal unifying insights. Here, we present the most comprehensive compend...

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Literature Corpus work: 67f2e21d-2c51-5eba-bc24-02f37ec7eafb
DOI: 10.21203/rs.3.rs-2049501/v1

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