Article

Meta-analysis of the amyotrophic lateral sclerosis spectrum uncovers genome instability

2022-08-18

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is characterised by progressive motor neuron degeneration but there is marked genetic and clinical heterogeneity 1 . Identifying common mechanisms of ALS amongst this diversity has been challenging, however, a systematic framework examining motor neurons across the ALS spectrum may reveal unifying insights. Here, we present the most comprehensive compendium of ALS human-induced...

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Literature Corpus work: 303eb4e4-85f3-5a96-bbd0-feca1dcc1414
DOI: 10.1101/2022.08.11.22278516

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