Article

Human iPSC-Derived Cardiomyocytes from ALS Patients with C9ORF72 Mutation Exhibit Cellular Hallmarks of ALS Pathology

2025-06-16

Abstract excerpt

<title>Abstract</title> Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting motor neurons. Recent clinical evidence points towards cardiac dysfunction as a contributing factor to ALS-related mortality. The <italic>C9ORF72</italic> hexanucleotide repeat expansion is the most common genetic cause of familial ALS, yet the effect of this mutation on human cardiomyocytes remai...

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Literature Corpus work: 246d3649-57cc-5db1-aa97-5f8b0a434270
DOI: 10.21203/rs.3.rs-6782801/v1

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