Genome editing: A perspective on the application of CRISPR/Cas9 to study human diseases (Review)

doi:10.3892/ijmm.2019.4112

Article

Genome editing: A perspective on the application of CRISPR/Cas9 to study human diseases (Review)

26 Feb 2019

Abstract excerpt

Genome editing reemerged in 2012 with the development of CRISPR/Cas9 technology, which is a genetic manipulation tool derived from the defense system of certain bacteria against viruses and plasmids. This method is easy to apply and has been used in a wide variety of experimental models, including cell lines, laboratory animals, plants, and even in human clinical trials. The CRISPR/Cas9 system consists of...

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