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Article

Cystic Fibrosis, CFTR, and Colorectal Cancer.

International journal of molecular sciences - 21 Apr 2020

Scott Patricia, Anderson Kyle, Singhania Mekhla, Cormier Robert

Abstract excerpt

Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, has recently been categorized as a familial colorectal cancer (CRC) syndrome. CF patients are highly susceptible to early, aggressive colorectal tumor development. Endoscopic screening studies have revealed that by the age of forty 50% of CF patients will develop adenomas, with...

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Identifiers

PMID: 32326161
DOI: 10.3390/ijms21082891
PMCID: PMC7215855

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