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The CYP27A1–VDR Feedback Rheostat Controls Mitochondrial Protein Homeostasis and Preserves Hippocampal-Striatal Network Integrity to rescue Cognitive impairment in HD condition

2026-06-16

Abstract excerpt

Emerging evidence links vitamin D (VD) deficiency to cognitive and motor dysfunction in Huntington’s disease (HD), yet the underlying mechanism remains unclear. Here, we combine in vitro genetic and 3-nitropropionic acid (3-NP)-induced in vivo models of HD to define the mechanistic basis of VD-mediated neuroprotection. We demonstrate that VD supplementation restores cognitive and motor deficits while improving m...

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Literature Corpus work: 67cb92a6-dfcf-5369-b163-eab35dc3f2e1
DOI: 10.64898/2026.06.11.731670

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