Article

Mdivi-1 affects neuronal activity by inhibition of Complex I and respiratory supercomplex assembly

2024-01-26

Abstract excerpt

Several human diseases, including cancer and neurodegeneration, are associated with excessive mitochondrial fragmentation. In this context, mitochondrial division inhibitor (Mdivi-1) has been tested as a therapeutic to block the fission-related protein dynamin-like protein-1 (Drp1). Recent studies suggest that Mdivi-1 interferes with mitochondrial bioenergetics. Here we show that the molecular mechanism of Mdivi-1...

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Literature Corpus work: 09e5184b-6e34-5933-a5ce-77d9887760c1
DOI: 10.1101/2024.01.25.577160

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