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Polydatin and Nicotinamide Rescue the Cellular Phenotype of Mitochondrial Diseases by Mitochondrial Unfolded Protein Response (mtUPR) Activation.

Biomolecules - 18 May 2024

Cilleros-Holgado Paula, Gómez-Fernández David, Piñero-Pérez Rocío, Romero Domínguez José Manuel, Talaverón-Rey Marta, Reche-López Diana, Suárez-Rivero Juan Miguel, Álvarez-Córdoba Mónica, Romero-González Ana, López-Cabrera Alejandra, Oliveira Marta Castro De, Rodríguez-Sacristan Andrés, Sánchez-Alcázar José Antonio

Abstract excerpt

Primary mitochondrial diseases result from mutations in nuclear DNA (nDNA) or mitochondrial DNA (mtDNA) genes, encoding proteins crucial for mitochondrial structure or function. Given that few disease-specific therapies are available for mitochondrial diseases, novel treatments to reverse mitochondrial dysfunction are necessary. In this work, we explored new therapeutic options in mitochondrial diseases using...

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Identifiers

PMID: 38786005
DOI: 10.3390/biom14050598
PMCID: PMC11118892

Genes

GFM1
SIRT3

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