Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and Opportunities

9 Feb 2021

Abstract excerpt

Substantial evidence indicates that mitochondrial impairment contributes to neuronal dysfunction and vulnerability in disease states, leading investigators to propose that the enhancement of mitochondrial function should be considered a strategy for neuroprotection. However, multiple attempts to improve mitochondrial function have failed to impact disease progression, suggesting that the biology underlying the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Mitochondrial Function and Pathology
Share to Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33572179
DOI: 10.3390/cells10020352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and OpportunitiesPMID 33572179Read ↗

Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease.Semantic proximity Read ↗

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disordersSemantic proximity Read ↗

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional CoactivatorsSemantic proximity Read ↗

PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria–nucleus signallingSemantic proximity Read ↗

PGC-1α at the intersection of bioenergetics regulation and neuron function: From Huntington's disease to Parkinson's disease and beyondSemantic proximity Read ↗

PGC-1α, mitochondrial dysfunction, and Huntington's diseaseSemantic proximity Read ↗

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseasesSemantic proximity Read ↗

Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic targetSemantic proximity Read ↗

Decreased mRNA Expression of PGC-1α and PGC-1α-Regulated Factors in the SOD1<sup>G93A</sup>ALS Mouse Model and in Human Sporadic ALSSemantic proximity Read ↗

A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice.Semantic proximity Read ↗

PGC-1 coactivators in the control of energy metabolismSemantic proximity Read ↗

PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular MetabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.