Atypical memory B cells acquire Breg phenotypes in hepatocellular carcinoma.

doi:10.1172/jci.insight.187025

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Article

Atypical memory B cells acquire Breg phenotypes in hepatocellular carcinoma.

JCI insight - 25 Feb 2025

Neo Shi Yong, Shuen Timothy Wai Ho, Khare Shruti, Chong Joni, Lau Maichan, Shirgaonkar Niranjan, Chua Levene, Zhao Junzhe, Lee Keene, Tan Charmaine, Ba Rebecca, Lim Janice, Chua Joelle, Cheong Hui Shi, Chai Hui Min, Chan Chung Yip, Chung Alexander Yaw Fui, Cheow Peng Chung, Jeyaraj Prema Raj, Teo Jin Yao, Koh Ye Xin, Chok Aik Yong, Chow Pierce Kah Hoe, Goh Brian, Wan Wei Keat, Leow Wei Qiang, Loh Tracy Jie Zhen, Tang Po Yin, Karunanithi Jayanthi, Ngo Nye Thane, Lim Tony Kiat Hon, Xu Shengli, Dasgupta Ramanuj, Toh Han Chong, Lam Kong-Peng

Abstract excerpt

The functional plasticity of tumor-infiltrating lymphocyte B-cells (TIL-B) spans from antitumor responses to noncanonical immune suppression. Yet, how the tumor microenvironment (TME) influences TIL-B development is still underappreciated. Our current study integrated single-cell transcriptomics and B cell receptor (BCR) sequencing to profile TIL-B phenotypes and clonalities in hepatocellular carcinoma (HCC)....

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PMID: 39998891
DOI: 10.1172/jci.insight.187025
PMCID: PMC11981623

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