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B cells expressing mutated IGHV1-69-encoded antigen receptors related to virus neutralization show lymphoma-like transcriptomes in patients with chronic HCV infection.

Hepatology communications - 1 Aug 2024

Schultheiß Christoph, Willscher Edith, Paschold Lisa, Ackermann Christin, Escher Moritz, Scholz Rebekka, Knapp Maximilian, Lützkendorf Jana, Müller Lutz P, Schulze Zur Wiesch Julian, Binder Mascha

Abstract excerpt

BACKGROUND: Chronic HCV infection leads to a complex interplay with adaptive immune cells that may result in B cell dyscrasias like cryoglobulinemia or lymphoma. While direct-acting antiviral therapy has decreased the incidence of severe liver damage, its effect on extrahepatic HCV manifestations such as B cell dyscrasias is still unclear. METHODS: We sequenced B cell receptor (BCR) repertoires in patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Identifiers

PMID: 39082968
DOI: 10.1097/HC9.0000000000000503

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