Article

Age-Dependent Outcomes of HBV Infection: An Integrated Conceptual Framework Linking Developmental Immunity, Tpex Dynamics, and Longitudinal Clinical Observations

2026-06-10

Abstract excerpt

HBV infection exhibits striking age-dependent outcomes: perinatal infection progresses to chronicity in ~90% of cases, whereas >95% of immunocompetent adults spontaneously clear infection. Conventional explanations invoking immune immaturity or tolerance fail to account for prolonged disease courses, intermittent ALT flares, heterogeneous antigen trajectories, or delayed functional cure. We synthesize emerging...

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Literature Corpus work: cad0abe2-b38e-521d-a4a5-c760d490af82
DOI: 10.20944/preprints202606.0811.v1

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