Article

Loss of epigenetic regulation disrupts lineage integrity, reactivates multipotency and promotes breast cancer

2021-10-24

Abstract excerpt

Systematically investigating the scores of genes mutated in cancer and discerning real drivers from inconsequential bystanders is a prerequisite for Precision Medicine, but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis screen to study 215 recurrent ‘long-tail’ breast cancer genes, which revealed epigenetic regulation as major tumor suppressive mechanism. We report that core or accessory...

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Identifiers and source

Literature Corpus work: 679eb5ff-df23-596a-a35a-20c34013ab4e
DOI: 10.1101/2021.10.22.465428

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