Article

A Multi-Layered Atlas of Spatial Regulatory Programs and Therapeutic Vulnerabilities in Glioblastoma

2025-09-27

Abstract excerpt

Glioblastoma (GBM) is marked by profound spatial heterogeneity. This complexity fuels tumor progression and therapy resistance. Although recent spatial transcriptomics (ST) studies have defined transcriptional niches, or metaprograms, the systems level regulatory logic linking upstream signaling, transcriptional programs, and therapeutic vulnerabilities remains unresolved. Here, we introduce an integrated, multi l...

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Literature Corpus work: 48a3abe5-af22-5ea3-9aaa-aae1fda4b1c6
DOI: 10.1101/2025.09.27.674707

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