Article

Establishment and equilibrium levels of deleterious mutations in large populations

2018-05-09

Abstract excerpt

Analytical and statistical stochastic approaches are used to model and predict the dispersion of mutations through a large population. These approaches are used to quantify the magnitude of a heterozygous selective advantage of a mutation in the presence of a homozygous disadvantage. Random effects such as genetic drift are accounted for, which are likely to extinguish even highly advantageous mutations while the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 674880d2-63bf-569e-b7ce-690d4be9cd9a
DOI: 10.1101/318428

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Establishment and equilibrium levels of deleterious mutations in large populationsDOI 10.1101/318428Read

Lethal mutations with fluctuating heterozygous effect: the lethal force of effective dominance.Semantic proximity Read

The rise and fall of deleterious mutation.Semantic proximity Read

Mutation-selection balance with multiple alleles.Semantic proximity Read

Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depressionSemantic proximity Read

Constraining models of dominance for nonsynonymous mutations in the human genomeSemantic proximity Read

A comprehensive representation of genotypic selection beyond two alleles, and its estimation from time-series dataSemantic proximity Read

Drop of Prevalence after Population Expansion: A lower prevalence for recessive disorders in a random mating population is a transient phenomenon during and after a growth phaseSemantic proximity Read

Dynamic mutation-selection balance as an evolutionary attractor.Semantic proximity Read

Expansion load: recessive mutations and the role of standing genetic variationSemantic proximity Read

Hidden role of mutations in the evolutionary process.Semantic proximity Read

Dynamics of unconditionally deleterious mutations: Gaussian approximation and soft selection.Semantic proximity Read

Agent-based modeling of DFNB1A prevalence with regard to intensity of selection pressure in isolated human population: will cochlear implantation increase the cases of hereditary deafness?Semantic proximity Read