Dynamic mutation-selection balance as an evolutionary attractor.

doi:10.1534/genetics.112.141291

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Article

Dynamic mutation-selection balance as an evolutionary attractor.

Genetics - 1 Aug 2012

Goyal Sidhartha, Balick Daniel J, Jerison Elizabeth R, Neher Richard A, Shraiman Boris I, Desai Michael M

Abstract excerpt

The vast majority of mutations are deleterious and are eliminated by purifying selection. Yet in finite asexual populations, purifying selection cannot completely prevent the accumulation of deleterious mutations due to Muller's ratchet: once lost by stochastic drift, the most-fit class of genotypes is lost forever. If deleterious mutations are weakly selected, Muller's ratchet can lead to a rapid degradation of...

Topics

Algorithms
Computer Simulation
Genetic Fitness
Genetics, Population
Models, Genetic
Mutation
Mutation Rate
Population Density
Reproduction, Asexual
Selection, Genetic

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Identifiers

PMID: 22661327
DOI: 10.1534/genetics.112.141291
PMCID: PMC3416009

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