Mutation-selection balance with multiple alleles.

Article

Mutation-selection balance with multiple alleles.

Genetica - 1 Jan 1998

Clark A G

Abstract excerpt

Human genetic disorders provide an extraordinary richness of data on the diversity of defective alleles. Well over 100 defective alleles for each of several human genetic disorders have been identified, including breast cancer (BRCA1), cystic fibrosis (CFTR), muscular dystrophy (DZM), and phenylk...

Topics

Alleles
BRCA1 Protein
Breast Neoplasms
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Female
Gene Frequency
Genetic Diseases, Inborn
Humans
Models, Genetic
Models, Statistical
Muscular Dystrophies
Mutation
Phenylketonurias
Selection, Genetic
Ureohydrolases

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.