Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The rise and fall of deleterious mutation.

Research in microbiology - 1 Dec 2007

Balbi Kevin J, Feil Edward J

Abstract excerpt

It is well established that selection is less efficient in small populations than in large ones. Here we review the impact of this effect by considering the gradual selective purging of deleterious mutation over time. We outline an approach to explore the dynamics of this process, and highlight its profound implications.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Archaea
Share to Bacteria
Share to Bacterial Physiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eukaryotic Cells

Share to Evolution, Molecular

Share to Genetic Drift

Share to Genomic Islands

Share to Selection, Genetic

Source

Identifiers

PMID: 17988836
DOI: 10.1016/j.resmic.2007.09.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The rise and fall of deleterious mutation.PMID 17988836Read ↗

When is selection effective?Semantic proximity Read ↗

Temporal Patterns of Deleterious Variations: Purifying Selection Across Evolutionary TimescalesSemantic proximity Read ↗

Population growth inflates the per-individual number of deleterious mutations and reduces their mean effect.Semantic proximity Read ↗

Deleterious Variation in Natural Populations and Implications for Conservation Genetics.Semantic proximity Read ↗

Deleterious passengers in adapting populations.Semantic proximity Read ↗

Fundamental concepts in genetics: effective population size and patterns of molecular evolution and variation.Semantic proximity Read ↗

Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?Semantic proximity Read ↗

Purging and accumulation of genetic load in conservation.Semantic proximity Read ↗

The dilemma of nearly neutral mutations. How important are they for evolution and human welfare?Semantic proximity Read ↗

Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depressionSemantic proximity Read ↗

Dynamic mutation-selection balance as an evolutionary attractor.Semantic proximity Read ↗

The effects of deleterious mutations on evolution at linked sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.