Article

Drop of Prevalence after Population Expansion: A lower prevalence for recessive disorders in a random mating population is a transient phenomenon during and after a growth phase

2021-09-30

Abstract excerpt

Despite increasing data from population-wide sequencing studies, the risk for recessive disorders in consanguineous partnerships is still heavily debated. An important aspect that has not sufficiently been investigated theoretically, is the influence of inbreeding on mutation load and incidence rates when the population sizes change. We therefore developed a model to study these dynamics for a wide range of growth...

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Literature Corpus work: 02eae449-07f7-5749-9d86-3ffda38b41ce
DOI: 10.1101/2021.09.29.462290

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Drop of Prevalence after Population Expansion: A lower prevalence for recessive disorders in a random mating population is a transient phenomenon during and after a growth phaseDOI 10.1101/2021.09.29.462290Read

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