Article

A genome-wide screen links peroxisome regulation with Wnt signaling through RNF146 and tankyrase

2024-02-04

Abstract excerpt

Peroxisomes are membrane-bound organelles harboring metabolic enzymes. In humans, peroxisomes are required for normal development, yet the genes regulating peroxisome function remain unclear. We performed a genome-wide CRISPRi screen to identify novel factors involved in peroxisomal homeostasis. We found that inhibition of RNF146, an E3 ligase activated by poly(ADP-ribose), reduced the import of proteins into pero...

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Literature Corpus work: 6730cf96-dd21-518b-918f-ddce9e338d8a
DOI: 10.1101/2024.02.02.578667

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