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Article

ATM functions at the peroxisome to induce pexophagy in response to ROS.

Nature cell biology - 1 Oct 2015

Zhang Jiangwei, Tripathi Durga Nand, Jing Ji, Alexander Angela, Kim Jinhee, Powell Reid T, Dere Ruhee, Tait-Mulder Jacqueline, Lee Ji-Hoon, Paull Tanya T, Pandita Raj K, Charaka Vijaya K, Pandita Tej K, Kastan Michael B, Walker Cheryl Lyn

Abstract excerpt

Peroxisomes are highly metabolic, autonomously replicating organelles that generate reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells must maintain peroxisome homeostasis, or risk pathologies associated with too few peroxisomes, such as peroxisome biogenesis disorders, or too many peroxisomes, inducing oxidative damage and promoting diseases such as cancer. We report...

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Source

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Identifiers

PMID: 26344566
DOI: 10.1038/ncb3230
PMCID: PMC4589490

Genes

ATM
PEX5
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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