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Article

A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders.

Disease models & mechanisms - 1 Sept 2011

Mast Fred D, Li Jing, Virk Maninder K, Hughes Sarah C, Simmonds Andrew J, Rachubinski Richard A

Abstract excerpt

Human peroxisome biogenesis disorders are lethal genetic diseases in which abnormal peroxisome assembly compromises overall peroxisome and cellular function. Peroxisomes are ubiquitous membrane-bound organelles involved in several important biochemical processes, notably lipid metabolism and the use of reactive oxygen species for detoxification. Using cultured cells, we systematically characterized the peroxisome...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21669930
DOI: 10.1242/dmm.007419
PMCID: PMC3180231

Genes

PEX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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