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Article

TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import.

The Journal of cell biology - 4 Sept 2017

Wang Wei, Xia Zhi-Jie, Farré Jean-Claude, Subramani Suresh

Abstract excerpt

Most proteins destined for the peroxisomal matrix depend on the peroxisomal targeting signals (PTSs), which require the PTS receptor PEX5, whose deficiency causes fatal human peroxisomal biogenesis disorders (PBDs). TRIM37 gene mutations cause muscle-liver-brain-eye (mulibrey) nanism. We found that TRIM37 localizes in peroxisomal membranes and ubiquitylates PEX5 at K464 by interacting with its C-terminal 51 amino...

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Share to Peroxisomes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28724525
DOI: 10.1083/jcb.201611170
PMCID: PMC5584156

Genes

PEX5
TRIM37
PTS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import.PMID 28724525Read ↗

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