Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.

PLoS genetics - 1 Jun 2017

Wangler Michael F, Chao Yu-Hsin, Bayat Vafa, Giagtzoglou Nikolaos, Shinde Abhijit Babaji, Putluri Nagireddy, Coarfa Cristian, Donti Taraka, Graham Brett H, Faust Joseph E, McNew James A, Moser Ann, Sardiello Marco, Baes Myriam, Bellen Hugo J

Abstract excerpt

Peroxisome biogenesis disorders (PBD) are a group of multi-system human diseases due to mutations in the PEX genes that are responsible for peroxisome assembly and function. These disorders lead to global defects in peroxisomal function and result in severe brain, liver, bone and kidney disease. In order to study their pathogenesis we undertook a systematic genetic and biochemical study of Drosophila pex16 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbohydrate Metabolism
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Glucose

Share to Membrane Proteins

Share to Peroxisomal Disorders

Share to Peroxisomes

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 28640802
DOI: 10.1371/journal.pgen.1006825
PMCID: PMC5480855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.PMID 28640802Read ↗

Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster.Semantic proximity Read ↗

A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders.Semantic proximity Read ↗

A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease.Semantic proximity Read ↗

A genetic screen for genes that impact peroxisomes in <i>Drosophila</i> identifies candidate genes for human diseaseSemantic proximity Read ↗

Drosophila Models Uncover Substrate Channeling Effects on Phospholipids and Sphingolipids in Peroxisomal Biogenesis DisordersSemantic proximity Read ↗

Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.Semantic proximity Read ↗

THE GENETICS OF PEROXISOME BIOGENESISSemantic proximity Read ↗

Peroxisome biogenesis disorders.Semantic proximity Read ↗

Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines.Semantic proximity Read ↗

Functional characterization of peroxisome biogenic proteins Pex5 and Pex7 of <i>Drosophila</i>Semantic proximity Read ↗

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants.Semantic proximity Read ↗

Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.