Article
The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders.
Autophagy - 4 May 2017
Law Kelsey B, Bronte-Tinkew Dana, Di Pietro Erminia, Snowden Ann, Jones Richard O, Moser Ann, Brumell John H, Braverman Nancy, Kim Peter K
Abstract excerpt
Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. The majority of PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) required for cycling PEX5 for peroxisomal matrix protein import. Mutations in these genes are thought to result in a defect in peroxisome assembly by preventing the import of matrix proteins....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.