Article

Peroxisome dysfunction alters metabolism of photoreceptor outer segments in human retinal pigment epithelium

2026-02-03

Abstract excerpt

Peroxisomes are ubiquitous organelles that compartmentalize metabolic reactions including lipid catabolism and cellular detoxification. Pathogenic variants in PEX1 and PEX6 disrupt essential peroxisome functions and cause profound neurodegenerative diseases called peroxisome biogenesis disorders (PBDs). Despite retinal degeneration and blindness occurring frequently in PBDs, precisely how impaired peroxisome act...

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Literature Corpus work: a1e09460-985f-5083-ab6b-ab18d8709182
DOI: 10.64898/2026.02.01.701576

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