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Sex- and age- differences in the expression of critical blood-brain barrier regulators: a physiological context

2 Sept 2025

Abstract excerpt

BACKGROUND: Available evidence indicates that blood-brain-barrier (BBB) dysfunction exacerbates with the advancing age and is implicated in a variety of neurological diseases and that there are significant sex differences in these diseases. However, the sex differences and age-related changes in BBB structure and function are still unclear under physiological conditions. METHODS: In this study, the mRNA was...

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PMID: 40898358
DOI: 10.1186/s13293-025-00751-2

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