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Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex‐dependent manner

7 Sept 2023

Abstract excerpt

Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase in the brain and contribute to brain damage and neurological disorders. Changes in the cerebral vasculature with aging may enhance iron entry into the brain parenchyma, leading to iron overload and its deleterious consequences. Endothelial senescence has emerged as an important contributor to age-related changes in the...

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PMID: 37675802
DOI: 10.1111/acel.13977

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