Article
Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype.
Microcirculation (New York, N.Y. : 1994) - 1 Feb 2024
Gulej Rafal, Csik Boglarka, Faakye Janet, Tarantini Stefano, Shanmugarama Santny, Chandragiri Siva Sai, Mukli Peter, Conley Shannon, Csiszar Anna, Ungvari Zoltan, Yabluchanskiy Andriy, Nyúl-Tóth Ádám
Abstract excerpt
INTRODUCTION: Age-related blood-brain barrier (BBB) disruption, cerebromicrovascular senescence, and microvascular rarefaction substantially contribute to the pathogenesis of vascular cognitive impairment (VCI) and Alzheimer's disease (AD). Previous studies established a causal link between age-related decline in circulating levels of insulin-like growth factor-1 (IGF-1), cerebromicrovascular dysfunction, and...
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