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Article

Characterization of the blood-brain barrier in genetically diverse laboratory mouse strains.

Fluids and barriers of the CNS - 28 Jul 2021

Schaffenrath Johanna, Huang Sheng-Fu, Wyss Tania, Delorenzi Mauro, Keller Annika

Abstract excerpt

BACKGROUND: Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants. Common laboratory mouse strains used for modelling human disease lack the genetic variability of the human population. Therefore, outcomes of rodent studies show limited relevance to human disease....

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Identifiers

PMID: 34321020
DOI: 10.1186/s12987-021-00269-w
PMCID: PMC8317333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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