Article

Single-cell RNA-seq analysis of human iPSC-derived motor neurons resolves early and predictive ALS signatures

2020-04-28

Abstract excerpt

<h4>Summary</h4> Induced pluripotent stem cell (iPSC) derived neural cultures from amyotrophic lateral sclerosis (ALS) patients can reflect disease phenotypes targetable by treatments. However, widely used differentiation protocols produce mixtures of progenitors, neurons, glia, and other cells at various developmental stages and rostrocaudal neural tube segments. Here we present a methodology using single-cell R...

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Literature Corpus work: 2896eb99-5549-5075-8491-18d2ad329851
DOI: 10.1101/2020.04.27.064584

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