CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling.

doi:10.1038/s41375-019-0661-z

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CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling.

Leukemia - 1 May 2020

Jin Xiaofeng, Shi Qing, Li Qian, Zhou Linyi, Wang Jian, Jiang Lei, Zhao Xiaying, Feng Kai, Lin Ting, Lin Zihan, Zhuang Hui, Yang Jianye, Hu Chongke, Zhang Luyi, Shen Liliang, Lu Ying, Zhu Jie, Wang Haibiao, Qi Honggang, Meng Xiaodan, Xi Yang, Pan Jinchang, Fang Shuai, Tian Haihua, Zhou Chengwei, Zhang Pingzhao, Gao Kun, Zhao Shi-Min, Li Yao, Gong Zhaohui, Wang Chenji

Abstract excerpt

Recurrent oncogenic mutations of MyD88 have been identified in a variety of lymphoid malignancies. Gain-of-function mutations of MyD88 constitutively activate downstream NF-κB signaling pathways, resulting in increased cellular proliferation and survival. However, whether MyD88 activity can be aberrantly regulated in MyD88-wild-type lymphoid malignancies remains poorly understood. SPOP is an adaptor protein of...

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PMID: 31776466
DOI: 10.1038/s41375-019-0661-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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