PINK1 Regulates Dopamine and Lipids at Mitochondria to Maintain Synapses and Neuronal Function

Abstract excerpt

Mitochondrial dysfunction contributes to the pathogenesis of Parkinson’s disease but it is not clear why inherent mitochondrial defects lead specifically to the death of dopaminergic neurons of the mid brain. PINK1 is mitochondrial kinase and PINK1 mutations cause early onset Parkinson’s disease. We found that in neuronal progenitors, PINK1 regulates mitochondrial morphology, mitochondrial contact to the endopla...

Topics

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• Autophagy
• Autophagy in Disease and Therapy
• Genes, Dominant
• Genes, Recessive
• Mitochondria
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

06142f95-d1c5-55ae-b5b0-9d2df05e11c3

DOI

10.1101/814343