Article

Oxidative switch drives mitophagy defects in dopaminergic <i>parkin</i> mutant patient neurons

2020-05-30

Abstract excerpt

<h4>Background: </h4> Mutations in parkin are the most common cause of early onset Parkinson’s disease. Parkin is an E3 ubiquitin ligase, functioning in mitophagy. Mitochondrial abnormalities are present in parkin mutant models. Patient derived neurons are a promising model in which to study pathogenic mechanisms and therapeutic targets. Here we generate induced neuronal progenitor cells from parkin mutant patient...

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Literature Corpus work: dcb136dd-9d8a-5b13-8dfa-a251470df418
DOI: 10.1101/2020.05.29.115782

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