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Article

iPS models of Parkin and PINK1.

Biochemical Society transactions - 1 Apr 2015

Rakovic Aleksandar, Seibler Philip, Klein Christine

Abstract excerpt

Parkinson disease (PD) is a degenerative disorder of the central nervous system resulting from depletion of dopaminergic neurons and currently remains incurable despite enormous international research efforts. The development of induced pluripotent stem cell (iPSC) technology opened up the unique possibility of studying disease mechanisms in human tissue that was otherwise not accessible, such as the brain. Of...

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Axons
Dopamine
Induced Pluripotent Stem Cells
Mitochondria
Nerve Degeneration
Parkinson Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinases

Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 25849934
DOI: 10.1042/BST20150010

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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