Article
Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment.
Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2022
Jarazo Javier, Barmpa Kyriaki, Modamio Jennifer, Saraiva Cláudia, Sabaté-Soler Sònia, Rosety Isabel, Griesbeck Anne, Skwirblies Florian, Zaffaroni Gaia, Smits Lisa M, Su Jihui, Arias-Fuenzalida Jonathan, Walter Jonas, Gomez-Giro Gemma, Monzel Anna S, Qing Xiaobing, Vitali Armelle, Cruciani Gerald, Boussaad Ibrahim, Brunelli Francesco, Jäger Christian, Rakovic Aleksandar, Li Wen, Yuan Lin, Berger Emanuel, Arena Giuseppe, Bolognin Silvia, Schmidt Ronny, Schröder Christoph, Antony Paul M A, Klein Christine, Krüger Rejko, Seibler Philip, Schwamborn Jens C
Abstract excerpt
BACKGROUND: The etiology of Parkinson's disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and specific gene mutations are contributors to the disease. Biallelic mutations in the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) gene involved in mitochondrial homeostasis, vesicle trafficking, and autophagy are sufficient to cause PD....
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