Article

Backup transcription factor binding sites protect human genes from mutations in the promoter

2023-01-27

Abstract excerpt

This study was designed to test the idea that human gene promoters have evolved to be resistant to the effects of mutations in their primary function, the control of gene expression. It is proposed that the transcription factor/transcription factor binding site (TF/TFBS) pair having the greatest effect on control of a gene is the one with the highest abundance in the promoter. Other pairs would have the same effec...

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Literature Corpus work: 66d4df29-19f9-5a6c-ac2a-bc65323724eb
DOI: 10.1101/2023.01.27.525856

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