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Article

Backup transcription factor binding sites protect human genes from mutations in the promoter.

PloS one - 1 Jan 2023

Brown Jay C

Abstract excerpt

This study was designed to test the idea that the regulatory regions of human genes have evolved to be resistant to the effects of mutations in their primary function, the control of gene expression. It is proposed that the transcription factor/transcription factor binding site (TF/TFBS) pair having the greatest effect on control of a gene is the one with the highest abundance among the regulatory elements. Other...

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Share to Binding Sites
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 37651425
DOI: 10.1371/journal.pone.0281569
PMCID: PMC10470901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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