Article
Tissue-specific transcriptional regulation has diverged significantly between human and mouse.
Nature genetics - 1 Jun 2007
Odom Duncan T, Dowell Robin D, Jacobsen Elizabeth S, Gordon William, Danford Timothy W, MacIsaac Kenzie D, Rolfe P Alexander, Conboy Caitlin M, Gifford David K, Fraenkel Ernest
Abstract excerpt
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species...
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