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Article

Diverse DNA methylation statuses at alternative promoters of human genes in various tissues.

DNA research : an international journal for rapid publication of reports on genes and genomes - 31 Aug 2006

Cheong Jieun, Yamada Yoichi, Yamashita Riu, Irie Takuma, Kanai Akinori, Wakaguri Hiroyuki, Nakai Kenta, Ito Takashi, Saito Izumu, Sugano Sumio, Suzuki Yutaka

Abstract excerpt

We characterized the DNA methylation status at 144 tissue-biased and 37 non-tissue-biased alternative promoters of 61 human genes in five normal tissues. Analysis of the collected data revealed that (i) DNA methylation status differed greatly among alternative promoters belonging to the same gene; (ii) DNA methylation status differed between tissues for the majority of the individual promoters, and (iii) 80-90%...

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PMID: 17068070
DOI: 10.1093/dnares/dsl008

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