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[Research advance of p53 gene in mantle cell lymphoma].

Zhongguo shi yan xue ye xue za zhi - 1 Jun 2011

Zhou Li-Tao, Zhu Jia-Bin

Abstract excerpt

Mantle cell lymphoma(MCL) is an independent uncommon subtype of B-cell non-Hodgkin's lymphoma (NHL) according to World Health Organization classification of hematopoietic and lymphoid tissue tumors. The genetic hallmark of MCL is the chromosomal translocation t(11;14)(q13;q32) that leads to upregulation of cyclin D1, an important regulator of the G(1) phase in the cell cycle. This genetic aberration is virtually...

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PMID: 21729583

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