Article

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002-06-15

Abstract excerpt

TGF-βs play diverse and complex roles in many biological processes. In tumorigenesis, they can function either as tumor suppressors or as pro-oncogenic factors, depending on the stage of the disease. We have developed transgenic mice expressing a TGF-β antagonist of the soluble type II TGF-β receptor:Fc fusion protein class, under the regulation of the mammary-selective MMTV-LTR promoter/enhancer. Biologically sig...

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Literature Corpus work: 66a3ed00-fa09-53f1-8092-e71a175e5901
DOI: 10.1172/jci200215333

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