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Article

Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.

Breast cancer research : BCR - 2 Jul 2012

Matise Lauren A, Palmer Trenis D, Ashby William J, Nashabi Abudi, Chytil Anna, Aakre Mary, Pickup Michael W, Gorska Agnieszka E, Zijlstra Andries, Moses Harold L

Abstract excerpt

INTRODUCTION: Transforming growth factor beta (TGF-β) has a dual role during tumor progression, initially as a suppressor and then as a promoter. Epithelial TGF-β signaling regulates fibroblast recruitment and activation. Concurrently, TGF-β signaling in stromal fibroblasts suppresses tumorigenes...

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Identifiers

PMID: 22748014
DOI: 10.1186/bcr3217
PMCID: PMC3680921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22748014-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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