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Article

Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model.

Cancer letters - 28 Apr 2014

Biswas Tanuka, Gu Xiang, Yang Junhua, Ellies Lesley G, Sun Lu-Zhe

Abstract excerpt

Previous studies have suggested that TGF-β functions as a tumor promoter in metastatic, mesenchymal-like breast cancer cells and that TGF-β inhibitors can effectively abrogate tumor progression in several of these models. Here we report a novel observation with the use of genetic and pharmacological approaches, and murine mammary cell injection models in both syngeneic and immune compromised mice. We found that...

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Source

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Identifiers

PMID: 24368187
DOI: 10.1016/j.canlet.2013.12.018
PMCID: PMC3947668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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