Article
NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.
Breast cancer research : BCR - 31 Aug 2011
Connelly Linda, Barham Whitney, Onishko Halina M, Chen Lianyi, Sherrill Taylor P, Zabuawala Tahera, Ostrowski Michael C, Blackwell Timothy S, Yull Fiona E
Abstract excerpt
INTRODUCTION: Metastasis from primary tumor to the lungs is a major cause of the mortality associated with breast cancer. Both immune and inflammatory responses impact whether circulating mammary tumor cells successfully colonize the lungs leading to established metastases. Nuclear factor -kappaB (NF-κB) transcription factors regulate both immune and inflammatory responses mediated in part by the activities of...
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