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Article

Restoration of TGF-β signalling reduces tumorigenicity in human lung cancer cells

25 Oct 2005

Abstract excerpt

Members of the transforming growth factor-beta (TGF-beta) family regulate a wide range of biological processes including cell proliferation, migration, differentiation, apoptosis, and extracellular matrix deposition. Resistance to TGF-beta-mediated tumour suppressor function in human lung cancer may occur through the loss of type II receptor (TbetaRII) expression. In this study, we investigated the expression...

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PMID: 16251876
DOI: 10.1038/sj.bjc.6602831

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