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Article

Dopaminergic neuronal loss and motor deficits in <i>Caenorhabditis elegans</i> overexpressing human α‐synuclein

13 Jun 2003

Abstract excerpt

Overexpression of human alpha-synuclein in model systems, including cultured neurons, drosophila and mice, leads to biochemical and pathological changes that mimic synucleopathies including Parkinson's disease. We have overexpressed both wild-type (WT) and mutant alanine53-->threonine (A53T) human alpha-synuclein by transgenic injection into Caenorhabditis elegans. Motor deficits were observed when either WT or...

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Identifiers

PMID: 12807436
DOI: 10.1046/j.1471-4159.2003.01809.x

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