Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling Parkinson's Disease in C. elegans.

Journal of Parkinson's disease - 1 Jan 2018

Cooper Jason F, Van Raamsdonk Jeremy M

Abstract excerpt

Parkinson's disease (PD) is an adult onset neurodegenerative disease that is characterized by selective degeneration of neurons primarily in the substantia nigra. At present, the pathogenesis of PD is incompletely understood and there are no neuroprotective treatments available. Accurate animal models of PD provide the opportunity to elucidate disease mechanisms and identify therapeutic targets. This review...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiparkinson Agents
Share to Dopaminergic Neurons
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Movement Disorders

Share to Nerve Degeneration

Share to Neurotoxins

Share to Parkinsonian Disorders

Share to Protein Aggregation, Pathological

Source

Open in PubMed Open full text

Identifiers

PMID: 29480229
DOI: 10.3233/JPD-171258
PMCID: PMC5836411

Genes

PINK1
PRKN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling Parkinson's Disease in C. elegans.PMID 29480229Read ↗

Modelling Parkinson's Disease in C. elegans : Strengths and LimitationsSemantic proximity Read ↗

Systematic Review of Caenorhabditis elegans Models for Mechanism Research and Drug Discovery in Parkinson’s DiseaseSemantic proximity Read ↗

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s DiseaseSemantic proximity Read ↗

Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond.Semantic proximity Read ↗

Traversing a wormhole to combat Parkinson's disease.Semantic proximity Read ↗

Studying the mechanisms of neurodegeneration: C. elegans advantages and opportunitiesSemantic proximity Read ↗

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease GenesSemantic proximity Read ↗

Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegansSemantic proximity Read ↗

Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson’s disease, Alzheimer’s disease and autism spectrum disorderSemantic proximity Read ↗

Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's diseaseSemantic proximity Read ↗

Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegansSemantic proximity Read ↗

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.